Review: cellular substrates of the eukaryotic chaperonin TRiC/CCT.

  title={Review: cellular substrates of the eukaryotic chaperonin TRiC/CCT.},
  author={Alex Dunn and Mark W Melville and Judith Frydman},
  journal={Journal of structural biology},
  volume={135 2},
The TCP-1 ring complex (TRiC; also called CCT, for chaperonin containing TCP-1) is a large (approximately 900 kDa) multisubunit complex that mediates protein folding in the eukaryotic cytosol. The physiological substrate spectrum of TRiC is still poorly defined. Genetic and biochemical data show that it is required for the folding of the cytoskeletal proteins actin and tubulin. Recent years have witnessed a steady stream of reports that describe other proteins that require TRiC for proper… CONTINUE READING

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