Review: Ultraviolet radiation and skin cancer

  title={Review: Ultraviolet radiation and skin cancer},
  author={Deevya L. Narayanan and Rao N. Saladi and Joshua L. Fox},
  journal={International Journal of Dermatology},
Skin cancer is the most common type of cancer in fair‐skinned populations in many parts of the world. The incidence, morbidity and mortality rates of skin cancers are increasing and, therefore, pose a significant public health concern. Ultraviolet radiation (UVR) is the major etiologic agent in the development of skin cancers. UVR causes DNA damage and genetic mutations, which subsequently lead to skin cancer. A clearer understanding of UVR is crucial in the prevention of skin cancer. This… 
UV Radiation and the Skin
Developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance are targeted.
Molecular and Genetic Response of Human Skin Under Ultraviolet Radiation
This chapter emphasizes on genetic and molecular mechanisms of pigmentation, tanning, DNA damage and repair, Melanocortin 1 receptor (MC1R) gene expression, photoproduct formation, and p53 mutation.
Ultraviolet radiation and melanoma.
Patterns of Ultraviolet Radiation Exposure and Skin Cancer Risk: the E3N-SunExp Study
Melanoma, BCC, and SCC are associated with different sun exposure profiles in women and high-sun protection factor sunscreen use before age 25 was associated with lower BCC risk, but use since age 25 and reapplication of sunscreen were associated with higher risks of all three types of skin cancer.
Skin Cancer Chemoprevention: Current Status and Future Potential
An overview on the skin cancer chemopreventive potential and mechanism of action of tested natural and synthetic agents and how these agents are present in daily diet and are supplemented or topically applied against prevention of various stages of skin cancer.
Non-melanoma skin cancer: contributory factors, treatment, and prevention
Non-melanoma skin cancers (NMSC), and melanoma skin cancer is prevalent worldwide and Australia and New Zealand have the highest rates of melanoma in the world.
Vitamin D serum levels and non-melanoma skin cancer risk
The results suggest that lower levels of vitamin D may be related to a reduced incidence of non-melanoma skin cancer.
Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography
The attenuation coefficient (μt) has a rising trend in the epidermis, but which shows a downward Trend in the dermis, which is conducive to understand the process of UVB-induced skin cancer and further be able to provide a reference for medical researchers.
Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs
In the authors' opinion, antisense oligonucleotides, which can be used in the form of targeted ointments, provide real hope as a treatment that will eliminate cancer cells near the tumor focus both before and after surgery.
Ultraviolet radiation-mediated development of cutaneous melanoma: An update.


The epidemiology of UV induced skin cancer.
Sun exposure and non-melanocytic skin cancer
Empirical evidence linking sun exposure and skin cancer coming from both descriptive studies in populations and analytical studies involving estimates of exposure in individuals is examined, with particular attention given to the quality of the published data.
Skin cancer in skin of color.
Mechanisms of induction of skin cancer by UV radiation.
The molecular events in the induction of skin cancer are being actively investigated, and recent research has added to the understanding of the roles of tumor suppressor and oncogenes in skin cancer.
Guidelines for School Programs to Prevent Skin Cancer
These guidelines were developed by CDC in collaboration with specialists in dermatology, pediatrics, public health, and education; national, federal, state, and voluntary agencies; schools; and other organizations.
Effectiveness of information campaigns.
The Protective Role of Melanin Against UV Damage in Human Skin †
The major acute and chronic effects of UVR on human skin, the properties of melanin, the regulation of pigmentation and its effect on skin cancer prevention are outlined.
An Analysis of UVA Emissions from Sunlamps and the Potential Importance for Melanoma
Typical sunlamp use results in an approximate doubling of annual effective dose, if the XFM action spectrum is applied, but frequent use can increase the annual effective XFM dose by as much as 6 times what would be received from the sun alone for fluorescent sunlamps and asMuch as 12 times for newer, high‐pressure sunlamping.
Occupation and skin cancer: the results of the HELIOS-I multicenter case-control study
Exposure to hazardous air pollutants, arsenic, ionizing radiations and burns may explain a good part of the associations observed in this study.
Mechanisms involved in ultraviolet light-induced immunosuppression.
  • F. Aubin
  • Biology, Medicine
    European journal of dermatology : EJD
  • 2003
Although the mechanisms by which immune regulatory suppressor T cells act still remain unclear, there is increasing evidence that apoptosis of epidermal LC or reactive T cells may play an important role through the Fas/FasL system.