• Corpus ID: 73493881

Review: The role of zinc in the endocrine system.

@article{Baltaci2019ReviewTR,
  title={Review: The role of zinc in the endocrine system.},
  author={Abdulkerim Kasim Baltaci and Rasim Mogulkoc and Saltuk Bugra Baltaci},
  journal={Pakistan journal of pharmaceutical sciences},
  year={2019},
  volume={32 1},
  pages={
          231-239
        }
}
Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Therefore, growth impairment, hypogonadism, and some… 

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References

SHOWING 1-10 OF 105 REFERENCES

Zinc and diabetes--clinical links and molecular mechanisms.

The role of zinc in growth and cell proliferation.

Evidence suggests that reduced zinc availability affects membrane signaling systems and intracellular second messengers that coordinate cell proliferation in response to IGF-I, and may directly regulate DNA synthesis through these systems.

[Zinc and the growth hormone system].

Zinc play an important role at receptor level, throughout various mechanisms (including a proven increase in receptor number, due to its aggregating membrane direct induced effect); moreover in this situation receptor resistance to IGF-I, that fades away after dietetic supplementation of the mineral, has been demonstrated.

ROLE OF ZINC IN GROWTH

It is concluded that the integration of these mechanisms contributes to the perfect physiological functioning of bone, causing the weight-height deficiency detected in several species studied, the human species in particular.

Actions and interactions of thyroid hormone and zinc status in growing rats.

Investigating the effects of hypothyroidism and hyperthyroidism in growing rats confirmed the role of both T3 and zinc in the regulation of growth and the somatotrophic axis, and the growth failure of zinc deficiency does not appear to be due to impaired T3 function.

Zinc and liver disease.

Clinical trials in human liver disease are limited in size and quality, but it is clear that zinc supplementation reverses clinical signs of zinc deficiency in patients with liver disease.

Effect of zinc on some biochemical indices of metabolism.

There is a relationship between zinc and some metabolic functions in healthy subjects without symptoms of zinc deficiency, and Serm thyroxins, effective thyroxine ratio and the immunoglobulins IgA showed a tendency to lower levels in subjects with low serum zinc.

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.

Zinc, exercise, and thyroid hormone function.

This review will focus on the relationship among zinc status, exercise, and thyroid hormone function.

Impact of the Discovery of Human Zinc Deficiency on Health

  • A. Prasad
  • Medicine, Biology
    Journal of the American College of Nutrition
  • 2009
A controlled clinical trial of zinc supplementation in patients with acrodermatitis enteropathica and Wilson's disease in order to document the preventive and therapeutic effects of zinc is warranted.
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