• Corpus ID: 73493881

Review: The role of zinc in the endocrine system.

  title={Review: The role of zinc in the endocrine system.},
  author={Abdulkerim Kasim Baltaci and Rasim Mogulkoc and Saltuk Bugra Baltaci},
  journal={Pakistan journal of pharmaceutical sciences},
  volume={32 1},
Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Therefore, growth impairment, hypogonadism, and some… 

Role of Zinc (Zn) in Human Reproduction: A Journey from Initial Spermatogenesis to Childbirth

The role of Zn and its supplementation in in vitro fertilization (IVF) opens opportunities for future studies on reproductive biology, as well as highlighting the role ofZn at each stage of human reproduction, from the spermatogenesis process to childbirth.

Mechanistic Impact of Zinc Deficiency in Human Development

It is concluded that the biofortified food is the best source of Zn as compared to the chemical supplementation to avoid their negative impacts on human.

Selected Essential and Toxic Chemical Elements in Hypothyroidism—A Literature Review (2001–2021)

The review found that disruption of the physiological levels of elements in the body adversely affects the functioning of cells and tissues, which can lead to the development of disease.

Zinc is a strong stimulant of metallothionein synthesis in the ischaemic testis tissue

A general evaluation of the results suggests that zinc supplementation is a strong stimulant of metallothionein synthesis in the ischaemic testis tissue.

Effectiveness of Zinc Supplementation on Lithium-Induced Alterations in Thyroid Functions

It is concluded that zinc may be an effective agent in normalizing the adverse effects caused by lithium on thyroid functions, and has been observed to have the capability to nearly normalize the altered 2-h uptake of 131I, biological and effective half-lives of131I, and circulating T4 levels that were altered after lithium treatment.

Maternal Vitamin D and its role in determining fetal origins of mental health.

A comprehensive overview of maternal vitamin D in determining the fetal origins of mental health is provided, with some references to the link between vitamin D levels, inflammatory responses to stress and mental disorders in adult life.

Association of Serum Zinc Levels in Overweight and Obesity

Low levels of zinc (Zn) have adverse effects on physiological and metabolic functions in humans, especially in processes linked with obesity, and this study demonstrated decreased serum Zn levels in overweight and obese individuals.

The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats

Combined zinc and melatonin therapy can contribute to the prevention of tumor growth by improving the disruption in element metabolism and suppressing IL-6 levels and reducing tissue damage that causes the cancer.

Conditional nutrition (I): concerning zinc as a beneficial but variable regulator of inflammation and experimental arthritis

This article extends the concept of conditional pharmacology that considers how both internal factors/disease and external/environmental factors may alter the availability or efficacy of exogenous drugs to some factors affecting the bioavailability and pharmaco-efficacy of dietary ionic zinc.



Zinc and diabetes--clinical links and molecular mechanisms.

The role of zinc in growth and cell proliferation.

Evidence suggests that reduced zinc availability affects membrane signaling systems and intracellular second messengers that coordinate cell proliferation in response to IGF-I, and may directly regulate DNA synthesis through these systems.

[Zinc and the growth hormone system].

Zinc play an important role at receptor level, throughout various mechanisms (including a proven increase in receptor number, due to its aggregating membrane direct induced effect); moreover in this situation receptor resistance to IGF-I, that fades away after dietetic supplementation of the mineral, has been demonstrated.


It is concluded that the integration of these mechanisms contributes to the perfect physiological functioning of bone, causing the weight-height deficiency detected in several species studied, the human species in particular.

Actions and interactions of thyroid hormone and zinc status in growing rats.

Investigating the effects of hypothyroidism and hyperthyroidism in growing rats confirmed the role of both T3 and zinc in the regulation of growth and the somatotrophic axis, and the growth failure of zinc deficiency does not appear to be due to impaired T3 function.

Zinc and liver disease.

Clinical trials in human liver disease are limited in size and quality, but it is clear that zinc supplementation reverses clinical signs of zinc deficiency in patients with liver disease.

Effect of zinc on some biochemical indices of metabolism.

There is a relationship between zinc and some metabolic functions in healthy subjects without symptoms of zinc deficiency, and Serm thyroxins, effective thyroxine ratio and the immunoglobulins IgA showed a tendency to lower levels in subjects with low serum zinc.

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.

Zinc, exercise, and thyroid hormone function.

This review will focus on the relationship among zinc status, exercise, and thyroid hormone function.

Impact of the Discovery of Human Zinc Deficiency on Health

  • A. Prasad
  • Medicine, Biology
    Journal of the American College of Nutrition
  • 2009
A controlled clinical trial of zinc supplementation in patients with acrodermatitis enteropathica and Wilson's disease in order to document the preventive and therapeutic effects of zinc is warranted.