• Corpus ID: 30301640

Review: Free radicals, antioxidants, and the immune system.

@article{Knight2000ReviewFR,
  title={Review: Free radicals, antioxidants, and the immune system.},
  author={Joseph A. Knight},
  journal={Annals of clinical and laboratory science},
  year={2000},
  volume={30 2},
  pages={
          145-58
        }
}
  • J. Knight
  • Published 1 April 2000
  • Biology, Medicine
  • Annals of clinical and laboratory science
Oxygen-derived free radicals are important in both natural and acquired immunity. Neutrophil and macrophage phagocytosis stimulates various cellular processes including the "respiratory burst" whereby increased cellular oxygen uptake results in the production of the potent oxidant bactericidal agents, hypochlorous acid and hydroxyl radical. In addition, nitric oxide, a gaseous radical produced by macrophages, reacts with superoxide to form peroxynitrite, also a potent bactericidal agent… 
View on PubMed
annclinlabsci.org
426 Citations
Highly Influential Citations
18
Background Citations
158
Methods Citations
4
Results Citations
4

Tables from this paper

426 Citations

Citation Type

Citation Type

Mitochondrial superoxide production is related to the control of cytokine release from peritoneal macrophage after antioxidant treatment in septic rats.
Effects of thiolic antioxidants on in vitro mouse peritoneal macrophage functions
TLDR
Tested antioxidants can lead to a decrease of the oxidative stress, and could provide a nutritional benefit for evaluated immunological characteristics.
Changes in lymphocyte oxidant/antioxidant parameters after carbonyl and antioxidant exposure.
Cumene hydroperoxide debilitates macrophage physiology by inducing oxidative stress: possible protection by alpha-tocopherol.
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
Effects of antioxidants on immune system ageing
  • M. Fuente
  • Biology
    European Journal of Clinical Nutrition
  • 2002
TLDR
Since the immune system is an indicator of health and a longevity predictor, the protection of this system afforded by dietary antioxidant supplementation may play an important role in order to achieve a healthy ageing.
Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils
Vitamin C and the Immune System
TLDR
The vital involvement of vitamin C in the regulation of the immune system to prevent tissue damage is described and how low levels of vitaminC may weaken the immuneSystem is discussed, which highlights the relevance of this essential nutrient for situations known to challenge the immune System.
Free radicals and antioxidants in human health: current status and future prospects.
TLDR
Current research reveals the different potential applications of antioxidant/free radical manipulations in prevention or control of disease.
Regulation of macrophage function by the antioxidant N-acetylcysteine in mouse-oxidative stress by endotoxin.
...
...

References

SHOWING 1-10 OF 127 REFERENCES
Free radicals in inflammation: second messengers and mediators of tissue destruction.
TLDR
It is argued that disturbances in the second messenger and regulatory activities of free radicals may also contribute significantly to the inflammatory process.
Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation.
TLDR
Antioxidants, together with agents interfering with the harmful effects of cytokines and lipid mediators, may have a role in the treatment of viral diseases and decrease the long-term effects of chronic oxidative stress, which have been linked to the development of cancer in some viral infections.
Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection.
A Biological Role for Ascorbate in the Selective Neutralization of Extracellular Phagocyte‐derived Oxidants
TLDR
The sustained release of RO by chronically activated phagocytes has been linked to the pathogenesis of some human diseases, and increased numbers of hyperactive macrophages and PMNL in the lungs of smokers with consequent chronic generation of phagocyte-derived R O may be involved in the etiology of smoking-related lung diseases.
Antioxidants and immune response in aged persons: overview of present evidence.
TLDR
The effects of antioxidants, vitamin E, beta-carotene, and glutathione on the immune response of aged persons is summarized and the underlying mechanisms for the antioxidant nutrients' effects as well as their health implications for aged persons are discussed.
Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2.
TLDR
Oral NAc-cys administration significantly decreased tumor progression in a refractory s.c. tumor model and may be useful as an adjunct to increase the antitumor activity of IL-2/LAK therapy.
Superoxide dependent iron release from ferritin in inflammatory diseases.
Role of nitric oxide synthesis in macrophage antimicrobial activity.
Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.
TLDR
The hypothesis that fluorescent monomeric and aggregated IgG may be formed in vivo by oxygen-centered free radicals derived from neutrophils, and that in rheumatoid inflammation this reaction may be self-perpetuating within the inflamed joint, is supported.
Effects of Antioxidant Vitamins C, E, and β‐Carotene on Immune Functions in MRL/Ipr Mice and Rats
TLDR
If the hypothesis is correct, slowing down the development of certain autoimmune diseases and consequently prolonging the life span in diseased animals should be possible by means of lowering the endogenous levels of free radicals using nutritional supplementation with antioxidants.
...
...