• Corpus ID: 30301640

Review: Free radicals, antioxidants, and the immune system.

  title={Review: Free radicals, antioxidants, and the immune system.},
  author={Joseph A. Knight},
  journal={Annals of clinical and laboratory science},
  volume={30 2},
  • J. Knight
  • Published 1 April 2000
  • Biology, Medicine
  • Annals of clinical and laboratory science
Oxygen-derived free radicals are important in both natural and acquired immunity. Neutrophil and macrophage phagocytosis stimulates various cellular processes including the "respiratory burst" whereby increased cellular oxygen uptake results in the production of the potent oxidant bactericidal agents, hypochlorous acid and hydroxyl radical. In addition, nitric oxide, a gaseous radical produced by macrophages, reacts with superoxide to form peroxynitrite, also a potent bactericidal agent… 

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