Corpus ID: 30301640

Review: Free radicals, antioxidants, and the immune system.

@article{Knight2000ReviewFR,
  title={Review: Free radicals, antioxidants, and the immune system.},
  author={J. Knight},
  journal={Annals of clinical and laboratory science},
  year={2000},
  volume={30 2},
  pages={
          145-58
        }
}
  • J. Knight
  • Published 2000
  • Biology, Medicine
  • Annals of clinical and laboratory science
Oxygen-derived free radicals are important in both natural and acquired immunity. Neutrophil and macrophage phagocytosis stimulates various cellular processes including the "respiratory burst" whereby increased cellular oxygen uptake results in the production of the potent oxidant bactericidal agents, hypochlorous acid and hydroxyl radical. In addition, nitric oxide, a gaseous radical produced by macrophages, reacts with superoxide to form peroxynitrite, also a potent bactericidal agent… Expand
Mitochondrial superoxide production is related to the control of cytokine release from peritoneal macrophage after antioxidant treatment in septic rats.
TLDR
Mitochondrial superoxide production seemed to be the differential oxidative parameter associated with antioxidant-induced modulation of cytokine release in peritoneal macrophages. Expand
Effects of thiolic antioxidants on in vitro mouse peritoneal macrophage functions
Since leukocytes have the potential to produce oxygen free radicals that damage biomolecules, we have evaluated the influence of thiolic antioxidants (glutathione, N-acetylcysteine and thioproline)Expand
Changes in lymphocyte oxidant/antioxidant parameters after carbonyl and antioxidant exposure.
TLDR
The association of astaxanthin and vitamin C proved to be a powerful antioxidant in human lymphocytes as showed by the marked reduction in superoxide anion, and hydrogen peroxide production as well as increased GSH content, GSH/GSSG ratio, GPx and GR activities. Expand
Cumene hydroperoxide debilitates macrophage physiology by inducing oxidative stress: possible protection by alpha-tocopherol.
TLDR
Exposure to Cum-OOH may impair the physiology of immune cells such as macrophages and that supplementation with alpha-tocopherol can safeguard these cells against Cum-ooH toxicity is suggested. Expand
Effects of antioxidants on immune system ageing
  • M. Fuente
  • Biology, Medicine
  • European Journal of Clinical Nutrition
  • 2002
TLDR
Since the immune system is an indicator of health and a longevity predictor, the protection of this system afforded by dietary antioxidant supplementation may play an important role in order to achieve a healthy ageing. Expand
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
TLDR
This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors. Expand
Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils
TLDR
Modification of cytoskeletal, metabolic, redox and signaling proteins that are critical for the NADPH oxidase mediated oxidative burst are detected and suggest that 4-HNE-induces a pleiotropic mechanism to inhibit neutrophil function. Expand
Free radicals and antioxidants in human health: current status and future prospects.
TLDR
Current research reveals the different potential applications of antioxidant/free radical manipulations in prevention or control of disease. Expand
Vitamin C and the Immune System
TLDR
The vital involvement of vitamin C in the regulation of the immune system to prevent tissue damage is described and how low levels of vitaminC may weaken the immuneSystem is discussed, which highlights the relevance of this essential nutrient for situations known to challenge the immune System. Expand
Regulation of macrophage function by the antioxidant N-acetylcysteine in mouse-oxidative stress by endotoxin.
TLDR
The data suggest that NAC administration may be useful for the treatment of oxidative stress-linked endotoxic shock, modulating the function of macrophages, specifically in decreasing the production of ROS and of inflammatory cytokines such as TNFalpha. Expand
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TLDR
If the hypothesis is correct, slowing down the development of certain autoimmune diseases and consequently prolonging the life span in diseased animals should be possible by means of lowering the endogenous levels of free radicals using nutritional supplementation with antioxidants. Expand
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