Review: Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent plasticity

@article{Hannan2014ReviewEE,
  title={Review: Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent plasticity},
  author={Anthony J. Hannan},
  journal={Neuropathology and Applied Neurobiology},
  year={2014},
  volume={40}
}
  • A. Hannan
  • Published 1 February 2014
  • Medicine
  • Neuropathology and Applied Neurobiology
Environmental enrichment (EE) increases levels of novelty and complexity, inducing enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found to have a range of effects, such as enhancing experience‐dependent cellular plasticity and cognitive performance, relative to standard‐housed controls. Whilst environmental enrichment is of course a relative term, dependent on the nature of control environmental conditions, epidemiological studies suggest that EE has direct… Expand
Is Environmental Enrichment Ready for Clinical Application in Human Post-stroke Rehabilitation?
TLDR
Preclinical stroke recovery studies that have successfully utilized EE to promote functional recovery and highlight the potential underlying mechanisms are summarized and how EE is being applied in a clinical setting is discussed. Expand
Developmental effects of environmental enrichment on selective and auditory sustained attention
TLDR
It is found that the exposure to enriched environment during mid-adolescence has yielded the most significant and long-term pattern of effects, including selective and auditory sustained attention performance, increased foraging-like behavior and a significant decrease in corticosterone level. Expand
Does Experience Enhance Cognitive Flexibility? An Overview of the Evidence Provided by the Environmental Enrichment Studies
  • F. Gelfo
  • Medicine, Psychology
  • Front. Behav. Neurosci.
  • 2019
TLDR
The summarized evidence clearly supports the specific beneficial effects of EE on CF, however, further studies on this key topic are strictly required to gain a comprehensive and detailed framework on the mechanisms by which an enhanced stimulation could improve CF. Expand
Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model
TLDR
EE was able to reduce locomotion and increase PPI in both strains, and to prevent the working memory deficit in SHRs. Expand
Differential impact of stress and environmental enrichment on corticolimbic circuits
TLDR
The literature on the morphological and molecular consequences of EE and stress in key emotional regulatory pathways in the brain, the hippocampus, prefrontal cortex, and amygdala are summarized, providing some insight into stress-EE interaction. Expand
Environmental enrichment is associated with rapid volumetric brain changes in adult mice
TLDR
Evidence from a second cohort of mice indicates that novel experiences are powerful modulators of plasticity even in the adult brain, and shows volumetric brain changes in brain areas related to spatial memory, navigation, and sensorimotor experience. Expand
Environmental enrichment enhances cognitive flexibility in C57BL/6 mice on a touchscreen reversal learning task
TLDR
The testing paradigm is capable of detecting EE‐induced improved cognitive flexibility in mice, which has implications for both understanding the mechanisms of EE and improving screening of putative cognitive‐enhancing therapeutics. Expand
Effect of Environmental Enrichment on Cognitive Impairment-induced by Ethanol Exposure in Adolescent Rat
Purpose: Adolescents who experienced the alcohol consumption have gradually increased. Adolescence is a critical period of the neural plasticity in the brain. Neural plasticity is mediated byExpand
Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k
TLDR
It is demonstrated that animals that have been exposed to one month of social or environmental enrichment demonstrate enhanced learning and memory relative to standard housed controls, and it is found that after 4months EE animals perform better than both SE and SC groups and demonstrate an enhanced hippocampal LTP. Expand
Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice
TLDR
In conclusion, EE improved the pain threshold reduction, long-term memory and synaptic plasticity deficits in nerve-injured mice; BDNF / Trk B signaling may contribute to the relief of long- term memory and neurotransmitter deficits induced by EE in nerve injured mice. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 189 REFERENCES
Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity
This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widelyExpand
The neurobiology of brain and cognitive reserve: Mental and physical activity as modulators of brain disorders
TLDR
Animal studies that have investigated the effects of modifying mental and physical activity via experimental manipulations are reviewed, and their relevance to brain and cognitive reserve (BCR) is discussed. Expand
Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice
TLDR
It is suggested that early EE has beneficial effects on the anxiety‐ like, but not on the depression‐like, behaviours in HD mice, and evidence is provided that 8‐OH‐DPAT induced hypothermia could be mediated by other targets besides the serotonin 5‐HT1A receptors. Expand
Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders
TLDR
Experimental evidence is reviewed showing that enriched environment can be beneficial in several psychiatric and neurodegenerative disorders implicating the monoamine systems and why some of the effects of environmental enrichment question the validity of current animal models of mental disorders. Expand
Long-term exposure to environmental enrichment since youth prevents recognition memory decline and increases synaptic plasticity markers in aging
TLDR
It is found that environmental factors have a positive impact on short-memory preservation, as well as on the maintenance of synapses and in the increase in number of new generated neurons within the hippocampus during aging. Expand
Enriched environments, experience-dependent plasticity and disorders of the nervous system
TLDR
Findings on the environmental modulators of pathogenesis and gene–environment interactions in CNS disorders, and their therapeutic implications, are reviewed. Expand
“Brain training” improves cognitive performance and survival in a transgenic mouse model of Huntington's disease
TLDR
Interestingly, providing cognitive stimulation via training in the OX maze produced significant improvements in subsequent cognitive performance by male, but not female, R6/2 mice in the Lashley maze task, and so warrants further study in rodent models of HD. Expand
Towards environmental construct validity in animal models of CNS disorders: optimizing translation of preclinical studies.
TLDR
It is proposed that therapeutic interventions which are found to show promise in standard-housed preclinical models should be subsequently tested under conditions of greater environmental enrichment to identify therapeutics which continue to show efficacy in housing contexts of superior 'environmental construct validity'. Expand
Effects of environmental manipulations in genetically targeted animal models of affective disorders
TLDR
The behavioral impairments exhibited by genetically targeted animal models of affective disorders are highlighted, and a discussion of the underlying neurobiology is provided, focusing on animal models that involve exposure to stress. Expand
The impact of environmental enrichment in laboratory rats—Behavioural and neurochemical aspects
TLDR
The findings summarised in the present review show the range of EE protocols employed and their effects in tests of activity, learning and affect, as well neurochemical effects which mediate enhanced plasticity in the brain. Expand
...
1
2
3
4
5
...