• Corpus ID: 4538888

Review: Cancer Morphogenesis: Role of Mitochondrial Failure

  title={Review: Cancer Morphogenesis: Role of Mitochondrial Failure},
  author={Egil Fosslien},
Adenosine triphosphate (ATP) required for normal cell metabolism is mainly supplied by mitochondrial oxidative phosphorylation (OXPHOS), which is limited by available oxygen and modulated by cell signaling pathways. Primary or secondary OXPHOS failure shifts cell metabolism towards ATP generation by glycolysis (Warburg effect). The objective of this paper is to clarify the role of mitochondrial dysfunction in cancer morphogenesis and to elucidate how faulty morphogen gradient signaling and… 

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