Review: Benzylpiperazine: a drug of abuse?

@article{Johnstone2007ReviewBA,
  title={Review: Benzylpiperazine: a drug of abuse?},
  author={Alice Christine Johnstone and Rod A. Lea and Katie Brennan and Susan Schenk and Martin Alexander Kennedy and Paul S Fitzmaurice},
  journal={Journal of Psychopharmacology},
  year={2007},
  volume={21},
  pages={888 - 894}
}
N-benzylpiperazine (BZP) is the active ingredient in recreational `party' or `p.e.p.' pills, which are used to provide a stimulant, euphoric effect akin to that of methylenedioxymethamphetamine (MDMA, `ecstasy'). BZP predominantly affects dopamine neurotransmission in a similar fashion to known `drugs of abuse', such as methamphetamine and cocaine, which strongly suggests BZP has abuse liability. BZP is illegal in many countries including the United States of America and Australia, yet it… 
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Background Citations
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26 Citations

Benzylpiperazine: "A messy drug".
Update on 1-benzylpiperazine (BZP) party pills
TLDR
The in vivo and in vitro studies performed in order to understand its pharmacology, toxicology and kinetics are discussed and analytical methodologies for the identification of BZP in clinical and forensic settings are addressed.
BZP-party pills: a review of research on benzylpiperazine as a recreational drug.
Recreational Drug Using Behaviour and Legal Benzylpiperazine Party Pills
Benzylpiperazine (BZP) is a stimulant drug that produces effects similar to amphetamines (Campbell, Cline, Evans, Lloyd, & Peck, 1973). It has been sold legally in New Zealand in the form of 'party…
Subjective effects in humans following administration of party pill drugs BZP and TFMPP alone and in combination.
The use of piperazine derivatives, colloquially named 'party pills', has been escalating in New Zealand and worldwide since their introduction in the 1990s. Benzylpiperazine (BZP) is often used…
1-Benzylpiperazine and other Piperazine-based Derivatives
Estrogenic effects and their action mechanism of the major active components of party pill drugs.
Nephrotoxic effects of common and emerging drugs of abuse.
TLDR
The nephrotoxic effects of these common and emerging drugs of abuse are discussed, of which both community and health care providers should become aware given their widespread abuse.
Designer Drug (DD) abuse in Poland; a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof. Part II--piperazines/piperidines, phenylethylamines, tryptamines and miscellaneous 'others'.
TLDR
These two articles may help suitable legislation to be rapidly devised to make the prohibition of DDs permanent whenever deemed necessary, as well as providing an up-to-date reference source for those engaged in the DD issue.
Adulthood Outcomes in Rats Following Repeated Adolescent Exposure to 1-Benzylpiperazine (BZP) and/or Ethanol.
TLDR
Overall, it appeared that adolescent exposure to BZP and/or alcohol did not have long-term behavioural consequences, at least in rats, which was most likely due to the narrow range of testing ages adopted in the study.
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TLDR
It was concluded that 1-benzylpiperazine is a compound liable to abuse by an addict population, and that this type of study might be of value in predicting abuse liability of other new drugs.
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N-Benzylpiperazine was tested in the beginning of the 1970s as a possible antidepressant drug. However, in both animal and human studies, it was shown to possess amphetamine-like properties, and any…
Chronic benzylpiperazine (BZP) exposure produces behavioral sensitization and cross-sensitization to methamphetamine (MA).
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TLDR
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TLDR
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