Review: BBN as an urothelial carcinogen.

  title={Review: BBN as an urothelial carcinogen.},
  author={C{\'a}rmen Vasconcelos-N{\'o}brega and Aura Antunes Colaço and Carlos Frederico Costa Lopes and Paula Alexandra Oliveira},
  journal={In vivo},
  volume={26 4},
Experimental urinary bladder tumours have been proposed as a useful model for the study of urinary bladder carcinogenesis, as well as for evaluating new therapeutic strategies. Consequently, the administration of chemical carcinogens is one of the most commonly used methods for inducing urinary bladder tumours. N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is, undoubtedly, the most-used urothelial chemical carcinogen. BBN belongs to the nitrosamine family, a wide group of alkylating agents that… CONTINUE READING