Review: Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications

@article{Montuschi2007ReviewAO,
  title={Review: Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications},
  author={Paolo Montuschi},
  journal={Theraputic Advances in Respiratory Disease},
  year={2007},
  volume={1},
  pages={23 - 5}
}
  • P. Montuschi
  • Published 1 October 2007
  • Medicine, Biology
  • Theraputic Advances in Respiratory Disease
Analysis of exhaled breath condensate (EBC) is a noninvasive method for studying the composition of airway lining fluid and has the potential for assessing lung inflammation. EBC is mainly formed by water vapor, but also contains aerosol particles in which several biomolecules including leukotrienes, 8-isoprostane, prostaglandins, hydrogen peroxide, nitric oxide-derived products, and hydrogen ions, have been detected in healthy subjects. Inflammatory mediators in EBC are detected in healthy… 
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118 Citations
Highly Influential Citations
3
Background Citations
28
Methods Citations
10

118 Citations

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Citation Type

Exhaled Breath Condensate Biomarkers of Airway Inflammation and Oxidative Stress in COPD
TLDR
Analysis of biomolecules in EBC is potentially useful for monitoring of lung inflammation and oxidative stress, which is an important component of inflammation, in patients with COPD.
Exhaled breath condensate in children: present knowledge and future prospects.
TLDR
Several biomarkers of airway inflammation and oxidative stress have been detected in the EBC of patients, demonstrating the role of different inflammatory pathways in the pathophysiology of respiratory diseases.
Exhaled breath condensate and airway inflammation
TLDR
Robust and easy-to-handle condensing devices and analytical methods are warranted to spread the use of EBC as inflammatory processes triggered may precede changes in lung function.
Role of Exhaled Biomarkers, Volatiles, and Breath Condensate
TLDR
The roles of volatile and nonvolatile biomarkers in the breath are reviewed and the full potential of this line of investigation in the occurrence of methodological and technological advancements is promising.
[EBC: a new matrix for assessment of airway and lung inflammation. Current aspects of environmental and occupational medicine].
TLDR
Exhaled breath condensate (EBC) is the liquid phase of the exhaled breath sampled by cooling and reflects acid stress, oxidative stress, or inflammation and is used for assessing airway inflammation in clinical practice, particularly in patients with asthma.
Exhaled breath condensate: determination of non-volatile compounds and their potential for clinical diagnosis and monitoring. A review.
Review on Exhaled Hydrogen Peroxide as a Potential Biomarker for Diagnosis of Inflammatory Lung Diseases
TLDR
The aim of this paper is to review and summarize the current methods being used to measure the concentration of H2O2 in EB to identify inflammatory lung diseases, and to discuss the advantages and disadvantages of these methods.
Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols.
Inflammatory mediators in exhaled breath condensate of healthy donors and exacerbated COPD patients.
Efficacy of two breath condensers
TLDR
Variability in gain was large and ECoScreen was more efficacious then RTube in condensing the tested solutes of HNL, but not those of MPO or chlorine J. Clin.
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References

SHOWING 1-10 OF 135 REFERENCES
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TLDR
Analysis of exhaled breath condensate in the future might contribute significantly to the understanding of the physiological and pathophysiological processes in lungs, to early detection, diagnosis and follow up of disease progression, and to evaluation of therapeutic response.
Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage.
TLDR
In clinical disease, markers of inflammation and oxidative stress are easily measurable in EBC using standard laboratory techniques and EBC is readily obtained, however, EBC and BAL markers do not correlate.
Exhaled breath condensate: an evolving tool for noninvasive evaluation of lung disease.
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  • Medicine
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  • 2002
TLDR
Characterized by uncertain and variable degrees of dilution, EBC does not provide precise assessment of individual solute concentrations within native airway lining fluid, but it can provide useful information when concentrations differ substantially between health and disease or are based on ratios of solutes found in the sample.
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TLDR
The aim of the American Thoracic Society/European Respiratory Society Task Force on EBC was to identify the important methodological issues surrounding EBC collection and assay, to provide recommendations for the measurements and to highlight areas where further research is required.
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TLDR
Results suggest that the proteins detected in breath originate partially from the naso-oropharyngeal tract and partially from lower regions of the airways.
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TLDR
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TLDR
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TLDR
The use of this modality in determining host inflammatory response to injury in the lung as well as possible future applications are focused on, particularly its potential use as a single, noninvasive sampling method for point-of-care real-time analysis.
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TLDR
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