Review: Adaptation in placental nutrient supply to meet fetal growth demand: implications for programming.

@article{Sibley2010ReviewAI,
  title={Review: Adaptation in placental nutrient supply to meet fetal growth demand: implications for programming.},
  author={Colin P Sibley and Paul Brownbill and Mark Robert Dilworth and Jocelyn D Glazier},
  journal={Placenta},
  year={2010},
  volume={31 Suppl},
  pages={S70-4}
}
This review considers the hypothesis that adaptations in blood flow, exchange surface area and transporter activity enable placental supply capacity to meet fetal demand and cause alterations in fetal composition which result in life-long programming of homeostatic set points. We consider the components of placental supply capacity and describe the predominant changes each of these could impose on solute and water exchange across the placenta. We next consider the evidence that adaptations in… CONTINUE READING
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