Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles.

@article{Duan2012ReversionOM,
  title={Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles.},
  author={Jinghua Duan and Heidi M. Mansour and Yangde Zhang and Xingming Deng and Yuxiang Chen and Jiwei Wang and Yifeng Pan and Jinfeng Zhao},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={426 1-2},
  pages={193-201}
}
Co-encapsulated doxorubicin (DOX) and curcumin (CUR) in poly(butyl cyanoacrylate) nanoparticles (PBCA-NPs) were prepared with emulsion polymerization and interfacial polymerization. The mean particle size and mean zeta potential of CUR-DOX-PBCA-NPs were 133 ± 5.34 nm in diameter and +32.23 ± 4.56 mV, respectively. The entrapment efficiencies of doxorubicin and curcumin were 49.98 ± 3.32% and 94.52 ± 3.14%, respectively. Anticancer activities and reversal efficacy of the formulations and various… CONTINUE READING