Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis.


Thyroid hormones (THs) and their DNA-binding nuclear receptors (TRs) direct transcriptional regulation in diverse ways depending on the host cell environment and specific promoter characteristics of TH-sensitive genes. This study sought to elucidate the impact on transcriptional repression of nucleotide sequence or orientation within TR binding sites - the… (More)
DOI: 10.1242/jcs.204222


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