Reversing the Warburg effect as a treatment for glioblastoma.

  title={Reversing the Warburg effect as a treatment for glioblastoma.},
  author={Ethan C Poteet and Gourav R Choudhury and Ali Winters and Wenjun Li and Myoung-Gwi Ryou and Ran Liu and Lin Tang and Anuja Ghorpade and Yi Wen and Fang Yuan and Stephen T Keir and Hai Yan and Darell D Bigner and James William Simpkins and Shao-Hua Yang},
  journal={The Journal of biological chemistry},
  volume={288 13},
Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the Warburg effect evidenced by the increasing of oxygen consumption and reduction of lactate production in GBM cell lines. MB decreases GBM cell proliferation and halts the cell cycle in S phase. Through activation of AMP-activated protein kinase, MB inactivates downstream acetyl-CoA carboxylase and… CONTINUE READING
Highly Cited
This paper has 632 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 28 extracted citations

633 Citations

Citations per Year
Semantic Scholar estimates that this publication has 633 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 54 references

Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington’s disease

E. M. Sontag, G. P. Lotz, +10 authors L. M. Thompson
models. J. Neurosci • 2012

Similar Papers

Loading similar papers…