Reversing the Life Cycle: Medusae Transforming into Polyps and Cell Transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa).

@article{Piraino1996ReversingTL,
  title={Reversing the Life Cycle: Medusae Transforming into Polyps and Cell Transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa).},
  author={Stefano Piraino and Ferdinando Boero and Bruno Aeschbach and Volker Schmid},
  journal={The Biological bulletin},
  year={1996},
  volume={190 3},
  pages={
          302-312
        }
}
Organisms develop through a series of stages leading to sexually mature adults. In a few cases ontogeny reversal is possible, but it does not occur typically after the onset of sexual reproduction. All stages of the medusa Turritopsis nutricula, from newly liberated to fully mature individuals, can transform back into colonial hydroids, either directly or through a resting period, thus escaping death and achieving potential immortality. This is the first metazoan known to revert to a colonial… 
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References

SHOWING 1-10 OF 67 REFERENCES
Development and Medusa-Bud Formation in the Hydromedusae
  • N. Berrill
  • Biology
    The Quarterly Review of Biology
  • 1950
TLDR
The following review represents an effort to bring together what is known concerning the developmental cycles of medusae as they occur beyond the reach of shore or floor of the sea, and the interest lies mainly in two activities, the development of medusa eggs directly into newmedusae, andThe processes of budding by the medusAE themselves.
An electron microscopic study of early developmental stages, myogenesis, oogenesis and cnidogenesis in the anthomedusa, Podocoryne carnea M. Sars
TLDR
The genealogy of cells participating in medusa differentiation indicates that some cell types of the medusa are derived by transdifferentiation from the polyp's epithelial cells, while others originate by differentiation from I‐cells.
Cell cycles and in vitro transdifferentiation and regeneration of isolated, striated muscle of jellyfish.
Genomic multipotentiality of differentiated somatic cells.
  • M. Diberardino
  • Biology
    Cell differentiation and development : the official journal of the International Society of Developmental Biologists
  • 1988
Proliferation kinetics and cell lineages can be studied in whole mounts and macerates by means of BrdU/anti-BrdU technique.
S-phase cells in intact animals of the coelenterate species Eirene viridula, Hydractinia echinata, Hydra attenuata, and Hydra magnipapillata incorporate the thymidine analogue bromodeoxyuridine…
Isolated, mononucleated, striated muscle can undergo pluripotent transdifferentiation and form a complex regenerate
Life stage specific expression of a myosin heavy chain in the hydrozoan Podocoryne carnea
TLDR
A monoclonal antibody was made that reacts with the filaments of striated muscle of the medusa stage that codes for the rod part of a myosing heavy chain (MHC) in a tissue specifically expressed cDNA of the metagenetic hydrozoan Podocoryne carnea.
Zoogeography and life cycle patterns of Mediterranean hydromedusae (Cnidaria)
The distribution of the 346 hydromedusan species hitherto recorded from the Mediterranean is considered, dividing the species into zoogeographical groups. The consequences for dispersal due to…
Experimentelle Untersuchungen über die Entstehung asexueller Klone bei der Hydromeduse Eleutheria dichotoma
Die Hydromeduse Eleutheria dichotoma pflanzt sich normalerweise sowohl geschlechtlich als auch vegetativ fort. In Klonkulturen treten jedoch als Ausnahmen sprunghaft asexuelle Medusen auf, welche die…
Activation of dormant genes in specialized cells.
TLDR
In several experimental systems the genomic capacity in specialized cells can be assessed by examining the activation of dormant genes, which indicates the ability of these cells to be induced to change cell phenotype.
...
...