Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

@article{Deidda2015ReversingEG,
  title={Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome},
  author={Gabriele Deidda and Martina Parrini and Shovan Naskar and Ignacio Fernandez Bozarth and Andrea Contestabile and Laura Cancedda},
  journal={Nature Medicine},
  year={2015},
  volume={21},
  pages={318-326}
}
Down syndrome (DS) is the most frequent genetic cause of intellectual disability, and altered GABAergic transmission through Cl−-permeable GABAA receptors (GABAARs) contributes considerably to learning and memory deficits in DS mouse models. However, the efficacy of GABAergic transmission has never been directly assessed in DS. Here GABAAR signaling was found to be excitatory rather than inhibitory, and the reversal potential for GABAAR-driven Cl− currents (ECl) was shifted toward more positive… CONTINUE READING
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