Reversing cerebellar long-term depression.

  title={Reversing cerebellar long-term depression.},
  author={Varda Lev-Ram and Samar Bharat Mehta and David Kleinfeld and Roger Tsien},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 26},
The discovery of a postsynaptically expressed form of cerebellar parallel fiber-Purkinje cell long-term potentiation (LTP) raises the question whether this is the long-sought resetting mechanism for long-term depression (LTD). Extracellular monitoring of PC spikes enables stable prolonged recordings of parallel fiber-Purkinje cell synaptic efficacy. LTD, saturated by repeated induction protocols, can be reversed by a single round of postsynaptic LTP or nitric oxide (NO), enabling LTD to be… CONTINUE READING
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