Reversible thermal denaturation of human FGF-1 induced by low concentrations of guanidine hydrochloride.

@article{Blaber1999ReversibleTD,
  title={Reversible thermal denaturation of human FGF-1 induced by low concentrations of guanidine hydrochloride.},
  author={Sachiko I. Blaber and J F Culajay and Anu Khurana and Michael Blaber},
  journal={Biophysical journal},
  year={1999},
  volume={77 1},
  pages={470-7}
}
Human acidic fibroblast growth factor (FGF-1) is a powerful mitogen and angiogenic factor with an apparent melting temperature (Tm) in the physiological range. FGF-1 is an example of a protein that is regulated, in part, by stability-based mechanisms. For example, the low Tm of FGF-1 has been postulated to play an important role in the unusual endoplasmic reticulum-independent secretion of this growth factor. Despite the close relationship between function and stability, accurate thermodynamic… CONTINUE READING
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