Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation

@inproceedings{Pocratsky2017ReversibleSO,
  title={Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation},
  author={Amanda Marie Pocratsky and Darlene A. Burke and Johnny R. Morehouse and Jason E Beare and Amberly S Riegler and Pantelis Tsoulfas and Gregory J R States and Scott R Whittemore and David S. K. Magnuson},
  booktitle={Nature Communications},
  year={2017}
}
Neural circuitry in the lumbar spinal cord governs two principal features of locomotion, rhythm and pattern, which reflect intra- and interlimb movement. These features are functionally organized into a hierarchy that precisely controls stepping in a stereotypic, speed-dependent fashion. Here, we show that a specific component of the locomotor pattern can be independently manipulated. Silencing spinal L2 interneurons that project to L5 selectively disrupts hindlimb alternation allowing a… CONTINUE READING
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