Reversible septal inactivation disrupts hippocampal slow-wave and unit activity and impairs trace conditioning in rabbits (Oryctolagus cuniculus).

@article{Asaka2002ReversibleSI,
  title={Reversible septal inactivation disrupts hippocampal slow-wave and unit activity and impairs trace conditioning in rabbits (Oryctolagus cuniculus).},
  author={Yukiko Asaka and Amy L. Griffin and S. D. Berry},
  journal={Behavioral neuroscience},
  year={2002},
  volume={116 3},
  pages={434-42}
}
This study investigated the effects of medial septal microinfusion of the local anesthetic, procaine (MS Pro), on hippocampal neurophysiology and learning of the rabbit (Oryctolagus cuniculus) classically conditioned jaw movement (CJM) response. Both the percentage and the amplitude of hippocampal theta decreased after procaine administration, and unit recordings from the MS Pro group showed significantly smaller conditioning-related hippocampal neural responses than those from controls. The MS… CONTINUE READING