Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity.


Reversible self-association of a monoclonal antibody (MAb) in a high concentration formulation results in a solution with a high viscosity. The nature of the self-association of full-length as well as antibody fragments has been studied by rheometry. Chaotropic anions reduced solution viscosity more than kosmotropic anions, a result that can be explained by… (More)
DOI: 10.1002/jps.21322


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics