Reversible posterior leukoencephalopathy syndrome in cancer

@article{Vaughn2008ReversiblePL,
  title={Reversible posterior leukoencephalopathy syndrome in cancer},
  author={Christopher J. Vaughn and Louann Zhang and David Schiff},
  journal={Current Oncology Reports},
  year={2008},
  volume={10},
  pages={86-91}
}
Reversible posterior leukoencephalopathy syndrome (RPLS) is a subacute neurological syndrome typically manifesting with headache, cortical blindness, and seizures. The syndrome is associated with risk factors such as malignant hypertension, eclampsia, and renal failure. Numerous case reports depict its occurrence in cancer patients. The direct causal relationship for the mechanism of RPLS in cancer patients has not yet been defined. Cytotoxic chemotherapy may cause direct endothelium damage… Expand
View on Springer
ncbi.nlm.nih.gov
80 Citations
Highly Influential Citations
6
Background Citations
28
Methods Citations
1

80 Citations

Citation Type

Citation Type

Reversible posterior leukoencephalopathy syndrome after carboplatin and paclitaxel regimen for lung cancer.
TLDR
The case of a 62-year-old man who was diagnosed with RPLS after receiving carboplatin and paclitaxel chemotherapy for lung cancer appears to be the first recognized association of RPLs with this regimen. Expand
Fatal posterior revesible leukoencephalopathy syndrome associated coma induced by bevacizumab in metastatic colorectal cancer and review of literature
TLDR
A case of fatal PRES-associated coma induced by bevacizumab in metastatic colorectal cancer is presented and a literature review was conducted by utilizing PubMed Database. Expand
Reversible posterior leukoencephalopathy induced by cancer chemotherapy.
TLDR
A diagnosis of reversible posterior leukoencephalopathy should be considered when patients receiving cancer chemotherapy suddenly develop hypertension followed by neurologic complications, especially if presenting with seizures. Expand
Reversible Posterior Leukoencephalopathy Syndrome Induced by Pazopanib
TLDR
The case of a 40 years old female patient with heavily pre-treated metastatic renal cell carcinoma who received pazopanib as salvage treatment is presented, which is the first case of pazobanib induced reversible posterior leukoencephalopathy syndrome. Expand
Reversible posterior leukoencephalopathy induced by carboplatin and etoposide
TLDR
The case of a 69-year-old lady who collapsed with seizure activity after receiving carboplatin and etoposide chemotherapy for small cell lung cancer is described. Expand
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
TLDR
A 34-year-old woman, diagnosed with invasive ductal carcinoma of the left breast, who experienced acute hypertension after vinorelbine intravenous infusion is reported, and the drug has not been described as a predisposing factor of RPLS in past reports. Expand
Reversible Posterior Leukoencephalopathy Syndrome Associated with Concurrent Bevacizumab, Gemcitabine, and Oxaliplatin for Cholangiocarcinoma
TLDR
The first reported case of RPLS associated with bevacizumab, gemcitabine, and oxaliplatin combination chemotherapy is presented and suggests that gradual progression of hypertension and proteinuria may be early warning signs before the onset of R PLS that should alarm clinicians. Expand
Atypical reversible posterior leukoencephalopathy syndrome (RPLS) induced by cediranib in a patient with metastatic rectal cancer
TLDR
RPLS is a rare, but serious, clinicoradiologic syndrome which has been described as an adverse effect of many anti-angiogenic agents and should also be considered in patients on cediranib who present with neurologic symptoms along with vasogenic edema seen on MRI. Expand
Reversible Posterior Leukoencephalopathy Syndrome after Eribulin Mesylate Chemotherapy for Breast Cancer
TLDR
A case of rare adverse events in a breast cancer patient who was undergoing eribulin chemotherapy who had generalized tonic-clonic seizure with eyeball deviation to right and loss of consciousness is reported. Expand
Reversible posterior leukoencephalopathy syndrome following apatinib for gastric cancer in an adult
TLDR
A case of Reversible posterior leukoencephalopathy syndrome induced by apatinib is presented and increased blood pressure may damage the normal blood-brain barrier, resulting in the extravasation of the fluid into the brain parenchyma. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Reversible posterior leukoencephalopathy syndrome complicating cytotoxic chemotherapy for hematologic malignancies
TLDR
Two cases of adults undergoing treatment for hematological malignancies who developed RPLS are reported, and the importance of early recognition and institution of appropriate management in reducing the risk of development of permanent neurological disability is emphasized. Expand
Chemotherapy induced reversible posterior leukoencephalopathy syndrome.
TLDR
The case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy is described. Expand
Hodgkin's disease-related central nervous system angiopathy presenting as reversible posterior leukoencephalopathy.
TLDR
A case of Hodgkin's disease (HD)-related central nervous system (CNS) angiitis with neuroimaging finding suggestive of reversible posterior leukoencephalopathy syndrome is described and the pathophysiology of RPLS in cases with CNSAngiitis is discussed. Expand
Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.
TLDR
Clinical and radiographic evidence consistent with reversible posterior leukoencephalopathy syndrome was found following the administration of irinotecan hydrochloride, leucovorin calcium, and fluorouracil (FOLFIRI) regimen chemotherapy and bevacizumab. Expand
A reversible posterior leukoencephalopathy syndrome.
TLDR
Reversible, predominantly posterior leukoencephalopathy may develop in patients who have renal insufficiency or hypertension or who are immunosuppressed and the findings on neuroimaging are characteristic of subcortical edema without infarction. Expand
Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome.
TLDR
Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Expand
Reversible posterior leukoencephalopathy in patients with systemic lupus erythematosus.
TLDR
It is likely that the clinical manifestations and neuroimages in these lupus patients were the result of the RPLE syndrome, and this cause of "secondary" CNS symptoms in patients with SLE is readily reversible when diagnosed early and treated with blood pressure control and supportive care. Expand
Posterior leukoencephalopathy syndrome
  • R. Garg
  • Medicine
  • Postgraduate medical journal
  • 2001
TLDR
Posterior leukoencephalopathy syndrome is a newly recognised brain disorder that predominantly affects the cerebral white matter that is clinically characterised by headache, nausea and vomiting, seizures, visual disturbances, altered sensorium, and occasionally focal neurological deficit. Expand
SIROLIMUS-INDUCED POSTERIOR REVERSIBLE ENCEPHALOPATHY
TLDR
This work presents a case of sirolimus-induced posterior reversible encephalopathy syndrome (PRES) with a lobar intracranial hemorrhage in a 51-year-old woman recipient of a single lung transplant 2 years prior to presentation. Expand
Reversible Posterior Leukoencephalopathy Syndrome after Treatment of Diffuse Large B-Cell Lymphoma
TLDR
The reversible posterior leukoencephalopathy syndrome is believed to be the result of altered cerebral autoregulation with impaired blood flow control and resultant endothelial damage caused by different situations and agents. Expand
...
1
2
3
4
...