Reversible posterior leukoencephalopathy syndrome in cancer

@article{Vaughn2008ReversiblePL,
  title={Reversible posterior leukoencephalopathy syndrome in cancer},
  author={Christopher J. Vaughn and Louann Zhang and David Schiff},
  journal={Current Oncology Reports},
  year={2008},
  volume={10},
  pages={86-91}
}
Reversible posterior leukoencephalopathy syndrome (RPLS) is a subacute neurological syndrome typically manifesting with headache, cortical blindness, and seizures. The syndrome is associated with risk factors such as malignant hypertension, eclampsia, and renal failure. Numerous case reports depict its occurrence in cancer patients. The direct causal relationship for the mechanism of RPLS in cancer patients has not yet been defined. Cytotoxic chemotherapy may cause direct endothelium damage… 

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References

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Posterior leukoencephalopathy syndrome

  • R. Garg
  • Medicine, Psychology
    Postgraduate medical journal
  • 2001
Posterior leukoencephalopathy syndrome is a newly recognised brain disorder that predominantly affects the cerebral white matter that is clinically characterised by headache, nausea and vomiting, seizures, visual disturbances, altered sensorium, and occasionally focal neurological deficit.

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This work presents a case of sirolimus-induced posterior reversible encephalopathy syndrome (PRES) with a lobar intracranial hemorrhage in a 51-year-old woman recipient of a single lung transplant 2 years prior to presentation.

Reversible Posterior Leukoencephalopathy Syndrome after Treatment of Diffuse Large B-Cell Lymphoma

The reversible posterior leukoencephalopathy syndrome is believed to be the result of altered cerebral autoregulation with impaired blood flow control and resultant endothelial damage caused by different situations and agents.