Reversible photo-regulation of a hammerhead ribozyme using a diffusible effector.

@article{Lee2007ReversiblePO,
  title={Reversible photo-regulation of a hammerhead ribozyme using a diffusible effector.},
  author={Hyun-Wu Lee and Stephen G. Robinson and Subhajit Bandyopadhyay and Reginald H. Mitchell and Dipankar Sen},
  journal={Journal of molecular biology},
  year={2007},
  volume={371 5},
  pages={
          1163-73
        }
}
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37 References

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A new principle for the regulation of ribozyme catalysis is established in which two regulatory factors (an oligonucleotide and a small molecule) that switch the ribo enzyme's activity in opposite directions compete for the same binding site in the aptamer domain.

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The rational design of the first protein-responsive allosteric ribozymes that are regulated by the HIV-1 Tat is reported, and two classes of TAR-modified hammerhead riboz enzymes and their response to Tat protein and to its derivatives are described.

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The remarkable versatility of nucleic acid catalysis is thus the fountainhead for wide-ranging applications of ribozymes and deoxyribozymes in biomedical and biotechnological research.