Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

@article{LahavBaratz1995ReversiblePC,
  title={Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.},
  author={S Lahav-Baratz and Valery Sudakin and Joan V. Ruderman and Avram Hershko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 20},
  pages={9303-7}
}
Cyclin B/cdc2 is responsible both for driving cells into mitosis and for activating the ubiquitin-dependent degradation of mitotic cyclins near the end of mitosis, an event required for the completion of mitosis and entry into interphase of the next cell cycle. Previous work with cell-free extracts of rapidly dividing clam embryos has identified two specific components required for the ubiquitination of mitotic cyclins: E2-C, a cyclin-selective ubiquitin carrier protein that is constitutively… CONTINUE READING
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