Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation.


A pH-responsive artificial selenoenzyme was constructed by reversible binding between organoselenium compound a1 nd CB[6] to form a pseudorotaxane-based molecular switch in response to pH stimuli. The glutathione peroxidase (GPx) activity of the artificial selenoenzyme can be switched on/off in a mild and body suitable environment between pH = 7 and pH = 6. 
DOI: 10.1039/c5cc02038g


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