Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.

@article{Luo2014ReversibleOO,
  title={Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.},
  author={Xiaoyang Luo and Wanxia He and Xiangyou Hu and Riqiang Yan},
  journal={Biological psychiatry},
  year={2014},
  volume={76 2},
  pages={120-7}
}
BACKGROUND Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule that regulates neural development, and mutation of Nrg1 is a risk factor for schizophrenia. Cleavage of type I β1 Nrg1 isoform by Bace1 releases a secreted N-terminal fragment (Nrg1-ntfβ), which can bind to a cognate ErbB receptor to activate the specific signaling cascade. This study aimed to determine whether increased expression of Nrg1 is beneficial for brain development and functions. METHODS We generated transgenic mice… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2013

Similar Papers

Loading similar papers…