Reversible monoamine oxidase-A inhibitors in panic disorder.

  title={Reversible monoamine oxidase-A inhibitors in panic disorder.},
  author={David Bakish and Bishan Saxena and Raymond C. Bowen and Juliet D'souza},
  journal={Clinical neuropharmacology},
  volume={16 Suppl 2},
Monoamine oxidase (MAO) inhibitors are known to be effective in panic disorder, but a high incidence of adverse reactions have limited their use. The new, selective, and reversible MAO-A inhibitors exemplified by brofaromine and moclobemide do not require dietary restrictions, have fewer drug interactions, and are better tolerated. This paper reports a randomized, double-blind, 8-week trial in which the efficacy and safety of brofaromine was compared to clomipramine in patients with panic… CONTINUE READING