Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.

  title={Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.},
  author={Jinbo Yang and Junji Huang and Maupali Dasgupta and Nathan Sears and Masaru Miyagi and Benlian Wang and Mark R. Chance and Xing Chen and Yuping Du and Yuxin Wang and Lizhe An and Qin Wang and Tao Lu and Xiaodong Zhang and Zhenghe Wang and George R Stark},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 50},
Following its tyrosine phosphorylation, STAT3 is methylated on K140 by the histone methyl transferase SET9 and demethylated by LSD1 when it is bound to a subset of the promoters that it activates. Methylation of K140 is a negative regulatory event, because its blockade greatly increases the steady-state amount of activated STAT3 and the expression of many (i.e., SOCS3) but not all (i.e., CD14) STAT3 target genes. Biological relevance is shown by the observation that overexpression of SOCS3 when… CONTINUE READING
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