Reversible lung lesions in rats due to short-term exposure to ultrafine cobalt particles.

@article{Kyono1992ReversibleLL,
  title={Reversible lung lesions in rats due to short-term exposure to ultrafine cobalt particles.},
  author={Hiroko Kyono and Yukinori Kusaka and Katsunori Homma and Hisayo Kubota and Yoko Endo-Ichikawa},
  journal={Industrial health},
  year={1992},
  volume={30 3-4},
  pages={
          103-18
        }
}
Using an ultrasonic nebulizer, cobalt aerosols (MMAD = 0.76 microns, sigma g = 2.1) were generated from an aqueous suspension of ultrafine metallic cobalt particles (Uf-Co) with a primary diameter of 20 nm. Rats were exposed to Uf-Co aerosols at 2.72 +/- 0.44 mg/m3 for 5 hours (Exp. 1) or at 2.12 +/- 0.55 mg/m3 for 4 days at 5 hours/day (Exp. 2). Only minimum histopathological changes were observed in the lungs in Exp. 1. In Exp. 2, evidence of slight injury was noted, including focal… CONTINUE READING
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