Reversible interaction of a reactive intermediate derived from furazolidone with glutathione and protein.

@article{Vroomen1988ReversibleIO,
  title={Reversible interaction of a reactive intermediate derived from furazolidone with glutathione and protein.},
  author={Louis H. M. Vroomen and M C Berghmans and John P. Groten and Jan Koeman and Peter J. van Bladeren},
  journal={Toxicology and applied pharmacology},
  year={1988},
  volume={95 1},
  pages={
          53-60
        }
}
Swine liver microsomes convert the nitrofuran furazolidone into N-(4-cyano-2-oxo-3-butenylidene)-3-amino-2-oxazolidone, a reactive open-chain acrylonitrile derivative. This derivative may be trapped with such thiol-group-containing agents as glutathione and mercaptoethanol. However, this reaction is reversible; e.g., adding an excess of mercaptoethanol to an aqueous solution (pH 7.4) of the glutathione conjugate results in conversion of 43% of this compound into the mercaptoethanol conjugate… CONTINUE READING

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The identification of potential alternative biomarkers of nitrofurazone abuse in animal derived food products.

  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2008
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CITES BACKGROUND

Transcriptional profile induced by furazolidone treatment of Shigella flexneri

  • Applied Microbiology and Biotechnology
  • 2007
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CITES RESULTS

Biological Reactive Intermediates IV

  • Advances in Experimental Medicine and Biology
  • 1991