Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.

@article{Mould2015ReversibleIO,
  title={Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.},
  author={Daniel P Mould and Alison E McGonagle and Daniel Howard Wiseman and Emma L. Williams and Allan M Jordan},
  journal={Medicinal research reviews},
  year={2015},
  volume={35 3},
  pages={586-618}
}
In the 10 years since the discovery of lysine-specific demethylase 1 (LSD1), this epigenetic eraser has emerged as an important target of interest in oncology. More specifically, research has demonstrated that it plays an essential role in the self-renewal of leukemic stem cells in acute myeloid leukemia (AML). This review will cover clinical aspects of AML, the role of epigenetics in the disease, and discuss the research that led to the first irreversible inhibitors of LSD1 entering clinical… CONTINUE READING
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