Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid.

@article{Davidson1986ReversibleIO,
  title={Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid.},
  author={James Seth Davidson and Ingrid M Baumgarten and E. H. Harley},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={134 1},
  pages={
          29-36
        }
}
Intercellular gap-junctional communication was measured using metabolic co-operation in co-cultures of argininosuccinate synthetase-deficient and argininosuccinate lyase-deficient human fibroblasts. 18-alpha-glycyrrhetinic acid (AGA) was found to inhibit communication by more than 95% at concentrations as low as 2 microM. Concentrations up to 100 microM were not cytotoxic over a period of 2 hours. Communication inhibition was of rapid onset and was readily reversible. Communication remained… CONTINUE READING
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