Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid.

@article{Applegate2008ReversibleIO,
  title={Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid.},
  author={Milana A B Applegate and Kenneth M Humphries and Luke I. Szweda},
  journal={Biochemistry},
  year={2008},
  volume={47 1},
  pages={473-8}
}
We have previously demonstrated that when cardiac mitochondria were challenged with H2O2, NADH production and oxidative phosphorylation declined. Upon consumption of H2O2, mitochondrial function was restored. These alterations were due, in large part, to reversible glutathionylation and inhibition of the Krebs cycle enzyme alpha-ketoglutarate dehydrogenase. The current study was undertaken to identify the site and consequences of alpha-ketoglutarate dehydrogenase glutathionylation. Mitochondria… CONTINUE READING
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