Reversible inhibition of a thyroid-specific trans-acting factor by Ras.

@article{Avvedimento1991ReversibleIO,
  title={Reversible inhibition of a thyroid-specific trans-acting factor by Ras.},
  author={Vittorio Enrico Avvedimento and A M Musti and Marius Ueffing and Silvana Obici and Adriana Martins Gallo and Mindy Sanchez and Daniele DeBrasi and Max E Gottesman},
  journal={Genes & development},
  year={1991},
  volume={5 1},
  pages={
          22-8
        }
}
  • Vittorio Enrico Avvedimento, A M Musti, +5 authors Max E Gottesman
  • Published in Genes & development 1991
  • Biology, Medicine
  • Exposure of rat thyroid cells for 1 week to a temperature-sensitive variant of Kirsten murine sarcoma virus (KiMSV) Ras inactivated the thyroglobulin promoter (pTg). Cellular dedifferentiation was paralleled by the loss of the thyroid-specific trans-acting factor, TgTF1, which binds to pTg. When Ras was denatured by shifting cells to 39 degrees C, TgTF1 binding and pTg function recovered rapidly without the synthesis of new protein. TgTF1 could be reactivated in vitro by treating nuclear… CONTINUE READING

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