Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease

@article{Kleopa2005ReversibleIA,
  title={Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease},
  author={Kleopas A Kleopa and Kyriacos C. Kyriacou and Eleni Zamba-Papanicolaou and Theodoros Kyriakides},
  journal={Muscle \& Nerve},
  year={2005},
  volume={31}
}
We report a patient with late‐onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti‐gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion‐body myositis. A gluten‐free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti… 
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An immune mediated pathogenesis for gluten-related neurological disorders is suggested, with changes observed in muscle in myopathy and in cerebrum of patients with encephalopathy and patients with epilepsy.
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The experience with 13 patients who presented with symptoms and signs suggestive of a myopathy and in whom investigation led to the diagnosis of gluten sensitivity shows clinical improvement of the myopathy with a gluten‐free diet.
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    Alternative medicine review : a journal of clinical therapeutic
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This review explores the etiology and pathology of celiac disease, presents support for the relationship between gluten and other diseases, and provides effective screening and treatment protocols.
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Positive status to HLA‐DQ2 allele, which is known to be more frequent in patients with inflammatory myopathies, could explain the high prevalence of antigliadin antibodies in this population.
Other Neurologic Disorders Associated with Gastrointestinal Disease
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Progress gained from research into sporadic inclusion body myositis indicates that both inflammatory reaction and abnormal protein accumulation are important for the pathogenesis in s-IBM.
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References

SHOWING 1-10 OF 43 REFERENCES
Brown bowel and skeletal myopathy associated with vitamin E depletion in pancreatic insufficiency.
CSF antigliadin antibodies and the Ramsay Hunt syndrome
TLDR
Celiac disease should be considered in the differential diagnosis of myoclonic ataxia at any age, even in the absence of clinical evidence of gluten-sensitive enteropathy, in this patient.
Reversibility of human myopathy caused by vitamin E deficiency
TLDR
A 7-year-old boy with severe malabsorption since birth who presented with progressive external ophthalmoplegia, proximal muscle weakness, peripheral neuropathy, hyporeflexia, and bilateral Babinski signs is described.
Ultrastructural and histochemical abnormalities of skeletal muscle in patients with chronic vitamin E deficiency
TLDR
By electronmicroscopy, the inclusions lying between myofibrils were membrane-bound dense bodies having characteristics of both lysosomes and lipopigment material and probably formed in response to disordered intracellular lipid peroxidation.
Cerebellar syndrome in adult celiac disease with vitamin E deficiency
TLDR
A woman with adult onset celiac disease complicated by a cerebellar syndrome that progressed despite the resolution of the malabsorption symptoms with a gluten free diet is studied, supporting the possible role of this deficiency in the development of the neurological complications of Celiac disease.
Celiac disease and spinocerebellar degeneration with normal vitamin E status
TLDR
The neurologic disorder initially deteriorated despite improvement of small bowel histology on a gluten-free diet and vitamin E therapy, but later stabilized.
Progressive ataxia, retinal degeneration, neuromyopathy, and mental subnormality in a patient with true hypoparathyroidism, dwarfism, malabsorption, and cholelithiasis
The patient described here has a rare association of signs and symptoms implicating the central and peripheral nervous systems, skeletal muscle, parathyroid glands, and gastrointestinal tract.…
Rhabdomyolysis in celiac disease.
TLDR
To the authors' knowledge this is the first childhood case of celiac disease presenting with rhabdomyolysis presented with chronic diarrhea, fatigue, failure to thrive, sudden weakness of her upper and lower extremities and inability to walk.
Neuromuscular dysfunction and ultrastructural pathology in children with chronic cholestasis and vitamin E deficiency
The ultrastructural pathology of nerve and muscle and the neurological dysfunction in children with cholestatic liver disease and vitamin E deficiency have not been previously correlated. We studied…
[A patient with vitamin E deficient, myopathy presenting with amyotrophy].
TLDR
A long-term workload due to hard physical labor and smoking in the patient may have accelerated oxidative muscle damage, resulting in amyotrophy mainly due to vitamin E deficient myopathy.
...
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4
5
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