Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease
@article{Kleopa2005ReversibleIA, title={Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease}, author={Kleopas A Kleopa and Kyriacos C. Kyriacou and Eleni Zamba-Papanicolaou and Theodoros Kyriakides}, journal={Muscle \& Nerve}, year={2005}, volume={31} }
We report a patient with late‐onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti‐gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion‐body myositis. A gluten‐free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti…
28 Citations
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Strict gluten-free diet is an effective first-line treatment of the neurological manifestations of gluten-related disorders and very few patients will require additional immunosuppressive treatment usually in the form of mycophenolate.
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- Medicine, BiologyNutrients
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The experience with 13 patients who presented with symptoms and signs suggestive of a myopathy and in whom investigation led to the diagnosis of gluten sensitivity shows clinical improvement of the myopathy with a gluten‐free diet.
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A 58-year-old French-Canadian man with 1 year of progressive leg stiffness and gait unsteadiness is investigated with mild, longstanding, biopsy-proven celiac disease, which has received replacement therapy for iron-deficiency anemia and vitamin B12 deficiency during the last decade.
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- MedicineAlternative medicine review : a journal of clinical therapeutic
- 2005
This review explores the etiology and pathology of celiac disease, presents support for the relationship between gluten and other diseases, and provides effective screening and treatment protocols.
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- MedicineCase reports in neurological medicine
- 2016
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- Medicine, PsychologyACG case reports journal
- 2016
It is demonstrated that in a patient with PFIC 2 and severe refractory vitamin E deficiency, liver transplant can improve vitamin E absorption, prevent further neurological sequelae, and reverse prior neurologic dysfunction.
Celiac disease and antibodies associated with celiac disease in patients with inflammatory myopathy
- Medicine, BiologyMuscle & nerve
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Positive status to HLA‐DQ2 allele, which is known to be more frequent in patients with inflammatory myopathies, could explain the high prevalence of antigliadin antibodies in this population.
Diagnosis, pathogenesis and treatment of inclusion body myositis
- BiologyCurrent opinion in neurology
- 2005
Progress gained from research into sporadic inclusion body myositis indicates that both inflammatory reaction and abnormal protein accumulation are important for the pathogenesis in s-IBM.
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