Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.

@article{Spoel2002ReversibleII,
  title={Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.},
  author={Aarnoud C van der Spoel and Mylvaganam Jeyakumar and Terry D. Butters and Harry M. Charlton and Harry D. M. Moore and Raymond A. Dwek and Frances M. Platt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 26},
  pages={
          17173-8
        }
}
During mammalian spermatogenesis, male germ cells undergo a dramatic transformation, which includes a change of shape, nuclear condensation, and development of specialised structures, such as an acrosome, and a flagellum with a mitochondrial sheath. We have found a previously undescribed pharmacological approach to intervene in these events. After oral administration of the alkylated imino sugar N-butyldeoxynojirimycin (NB-DNJ) to mice, epididymal spermatozoa displayed a spectrum of abnormal… CONTINUE READING

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