Reversible inactivation of autosomal alleles in Chinese hamster cells.


Evidence is presented which suggests that a CHO-derived thymidine kinase (Tk) heterozygote, ts201, can reversibly inactivate the wild type Tk allele, and that this event may result in simultaneous inactivation of a linked allele, galactokinase (Glk). The clone ts201 was isolated as a revertant of a stable Tk- 5-bromodeoxyuridine (BrdU)-resistant mutant of… (More)


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