Reversible glutathionylation of complex I increases mitochondrial superoxide formation.

@article{Taylor2003ReversibleGO,
  title={Reversible glutathionylation of complex I increases mitochondrial superoxide formation.},
  author={Ellen Riddle Taylor and Fiona Hurrell and Richard J. Shannon and Tsu-Kung Lin and Judy Hirst and Michael P Murphy},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 22},
  pages={
          19603-10
        }
}
Increased production of reactive oxygen species (ROS) by mitochondria is involved in oxidative damage to the organelle and in committing cells to apoptosis or senescence, but the mechanisms of this increase are unknown. Here we show that ROS production by mitochondrial complex I increases in response to oxidation of the mitochondrial glutathione pool. This correlates with thiols on the 51- and 75-kDa subunits of complex I forming mixed disulfides with glutathione. Glutathionylation of complex I… CONTINUE READING
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