Reversible formation of fatty acid esters of budesonide, an antiasthma glucocorticoid, in human lung and liver microsomes.

@article{Tunek1997ReversibleFO,
  title={Reversible formation of fatty acid esters of budesonide, an antiasthma glucocorticoid, in human lung and liver microsomes.},
  author={Anders Tunek and Kristina Sj{\"o}din and G Hallstr{\"o}m},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1997},
  volume={25 11},
  pages={1311-7}
}
Microsomes from human lung and liver catalyze the formation of fatty acid esters of budesonide, a glucocorticoid used for inhalation treatment of asthma. The conjugation was dependent on coenzyme A and ATP. Addition of free fatty acids to the incubations affected the pattern of metabolites, but ester formation was observed also without such addition. Budesonide oleate, palmitate, linoleate, palmitoleate, and arachidonate were identified as metabolites. The fatty acid conjugates of budesonide… CONTINUE READING

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