Reversible expression of CD34 by adult human bone marrow long-term engrafting hematopoietic stem cells.

@article{Zanjani2003ReversibleEO,
  title={Reversible expression of CD34 by adult human bone marrow long-term engrafting hematopoietic stem cells.},
  author={Esmail D. Zanjani and Graça Almeida-Porada and Anne G Livingston and Haiqun Zeng and Makio Ogawa},
  journal={Experimental hematology},
  year={2003},
  volume={31 5},
  pages={406-12}
}
OBJECTIVE We previously reported that CD34(-) population of bone marrow (BM) cells from adult humans contains cells capable of engraftment and multilineage differentiation. We also reported on the reversibility of CD34 expression by murine hematopoietic stem cells. Based on long-term observations in primary, secondary, and tertiary sheep recipients, we now present definitive evidence for the long-term engrafting capability of human BM CD34(-) cells, and the reversibility of CD34 expression by… CONTINUE READING

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