Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.

Abstract

Superoxide dismutase (SOD) rapidly scavenges superoxide (O2-) and also prolongs the vasorelaxant effects of nitric oxide (NO), thought to be the endothelium-derived relaxing factor. This prolongation has been ascribed to prevention of the reaction between O2- with NO. We report that SOD supports a reversible reduction of NO to NO-. When cyanamide and… (More)

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@article{Murphy1991ReversibleCO, title={Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.}, author={Michael E P Murphy and Helmult Sies}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1991}, volume={88 23}, pages={10860-4} }