Reversible contraception in female baboons immunized with a synthetic epitope of sperm-specific lactate dehydrogenase.

@article{OHern1995ReversibleCI,
  title={Reversible contraception in female baboons immunized with a synthetic epitope of sperm-specific lactate dehydrogenase.},
  author={P. O'Hern and C. Bambra and M. Isahakia and E. Goldberg},
  journal={Biology of reproduction},
  year={1995},
  volume={52 2},
  pages={
          331-9
        }
}
In previous experiments, the sperm-specific isozyme of lactate dehydrogenase (LDH-C) had been purified from mouse testes and shown to suppress the fertility of female baboons by 70% compared to controls. Although these results demonstrated the feasibility of this approach for contraceptive vaccine development, it is not practical to purify enough of the protein from natural sources for human use. Therefore, a need exists to develop a contraceptive vaccine based on synthetic peptides. In the… Expand
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