Reversible conformational switch revealed by the redox structures of Bacillus subtilis thiol peroxidase.


Bacterial thiol peroxidase (Tpx) is the periplasmic antioxidant enzyme widely distributed in most bacterial species, which catalyzes the reduction of lipid hydroperoxide in vivo. Tpx belongs to the atypical 2-Cys peroxiredoxin (Prx) family and utilizes two active cysteine residues during the redox reaction. Although several crystal structures of Tpx are… (More)
DOI: 10.1016/j.bbrc.2008.06.051


4 Figures and Tables