Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders

@article{Priest1995ReversibleAS,
  title={Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders},
  author={Robert G. Priest and R. Gimbrett and Matthew Roberts and J. Steinert},
  journal={Acta Psychiatrica Scandinavica},
  year={1995},
  volume={91}
}
The clinically tested reversiblc inhibitors of monoamine oxidase A (RIMAs) include brofaromine, moclobemide and toloxatone. Moclobemide has shown unequivocal antidepressant activity against serious deprcssivc illness in 4 placebo‐controlled double‐blind trials. It has been compared with amitriptyline, imipramine, clomipramine, desipramine, maprotiline, fluoxetine, fluvoxamine, tranylcypromine. toloxatone, mianserin and amineptine in the treatment of depressive disorders. Meta‐analysis showed… 
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Reversible and irreversible monoamine oxidase inhibitors in other psychiatric disorders
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TLDR
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TLDR
Moclobemide, a specific reversible inhibitor of monoamine oxidase that shows a preference for the A isoenzyme, has been developed as a new antidepressive agent that is devoid of any clinically significant tyramine interaction, thus making dietary restrictions during therapy unnecessary.
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TLDR
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