Reversible and irreversible nodal dysfunction in diabetic neuropathy.

  title={Reversible and irreversible nodal dysfunction in diabetic neuropathy.},
  author={Tom Brismar and Anders A. F. Sima and Douglas A. Greene},
  journal={Annals of neurology},
  volume={21 5},
Acute reversible diabetic nerve dysfunction has been associated with a reversible myo-inositol-related (Na+ + K+)-ATPase defect, while poorly reversible chronic nerve dysfunction correlates with progressive axoglial dysjunction of peripheral nerve. The causal relationships between biochemical and neuroanatomical abnormalities and those of nodal membrane function are not known. Nodal clamp examinations were carried out in the sciatic nerve of diabetic BB-rats to elucidate the events underlying… CONTINUE READING
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