Reversible adipose tissue enlargement induced by external tissue suspension: possible contribution of basic fibroblast growth factor in the preservation of enlarged tissue.

@article{Kato2010ReversibleAT,
  title={Reversible adipose tissue enlargement induced by external tissue suspension: possible contribution of basic fibroblast growth factor in the preservation of enlarged tissue.},
  author={Harunosuke Kato and Hirotaka Suga and Hitomi Eto and Jun Araki and Noriyuki Aoi and Kentaro Doi and Takuya Iida and Yasuhiko Tabata and Kotaro Yoshimura},
  journal={Tissue engineering. Part A},
  year={2010},
  volume={16 6},
  pages={2029-40}
}
Various kinds of tissue expansion have been performed clinically with internal devices, but external expansion has not been previously investigated. We applied continuous external force on skin tissue in a mouse model. Four weeks of external suspension caused enlargement of the subcutaneous tissue, particularly adipose tissue, although the enlargement was reversible. We found that the enlarged tissue volume could be adequately sustained with controlled release of basic fibroblast growth factor… CONTINUE READING
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