Reversible Suppression of Glutamatergic Neurotransmission of Cerebellar Granule Cells In Vivo by Genetically Manipulated Expression of Tetanus Neurotoxin Light Chain

@article{Yamamoto2003ReversibleSO,
  title={Reversible Suppression of Glutamatergic Neurotransmission of Cerebellar Granule Cells In Vivo by Genetically Manipulated Expression of Tetanus Neurotoxin Light Chain},
  author={M. Yamamoto and N. Wada and Y. Kitabatake and Dai Watanabe and M. Anzai and M. Yokoyama and Y. Teranishi and S. Nakanishi},
  journal={The Journal of Neuroscience},
  year={2003},
  volume={23},
  pages={6759 - 6767}
}
  • M. Yamamoto, N. Wada, +5 authors S. Nakanishi
  • Published 2003
  • Medicine, Biology
  • The Journal of Neuroscience
  • We developed a novel technique that allowed reversible suppression of glutamatergic neurotransmission in the cerebellar network. We generated two lines of transgenic mice termed Tet and TeNT mice and crossed the two transgenic lines to produce the Tet/TeNT double transgenic mice. In the Tet mice, the tetracycline-controlled reverse activator (rtTA) was expressed selectively in cerebellar granule cells by the promoter function of the GABAA receptor α6 subunit gene. In the TeNT mice, the fusion… CONTINUE READING
    Rapid and Reversible Chemical Inactivation of Synaptic Transmission in Genetically Targeted Neurons
    96
    Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo
    15

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 71 REFERENCES
    Directing gene expression to cerebellar granule cells using γ-aminobutyric acid type A receptor α6 subunit transgenes
    41
    Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
    329
    Inducible and Reversible Gene Expression with the rtTA System for the Study of Memory
    244