Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor.

@article{Winkler1997ReversibleSC,
  title={Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor.},
  author={J{\"u}rgen Winkler and Gustavo Ramirez and Hans Georg Kuhn and Daniel A. Peterson and Patricia Ann Day-Lollini and George R. Stewart and Mark H Tuszynski and Fred H. Gage and LeonJ. Thal},
  journal={Annals of neurology},
  year={1997},
  volume={41 1},
  pages={
          82-93
        }
}
Substantial dysfunction and loss of cholinergic neurons occur in Alzheimer's disease (AD). Nerve growth factor (NGF) is a potent neurotrophic factor for cholinergic basal forebrain neurons, and the use of NGF to stimulate residual dysfunctional cells in AD is being considered. To define the effects of NGF on other cell populations in the brain, NGF was continuously infused into the lateral ventricle of rats for 7 weeks. At the end of treatment, Schwann cell hyperplasia and abundant sensory and… CONTINUE READING
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