Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity

@article{Lichtman2004ReversibleIO,
  title={Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity},
  author={A. Lichtman and D. Leung and C. Shelton and A. Saghatelian and C. Hardouin and D. Boger and B. Cravatt},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={311},
  pages={441 - 448}
}
Fatty acid amide hydrolase (FAAH) is the primary catabolic regulator of several bioactive lipid amides in vivo, including the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. Inhibitors of FAAH are considered a potential therapeutic approach for the treatment of several nervous system disorders, including pain, anxiety, and insomnia. However, for FAAH inhibitors to achieve clinical utility, they must not only display efficacy in vivo but also selectivity for this… Expand
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