Reversible Crystallization of Argatroban after Subcutaneous Application in Pigs

@inproceedings{Lpez2012ReversibleCO,
  title={Reversible Crystallization of Argatroban after Subcutaneous Application in Pigs},
  author={Mercedes L L{\'o}pez and Goetz Nowak},
  booktitle={Thrombosis},
  year={2012}
}
Argatroban is a thrombin inhibitor used as anticoagulant in patients with heparin-induced thrombocytopenia. It is usually administered as an intravenous bolus followed by infusion. Nevertheless, its pharmacokinetics after subcutaneous administration is unknown. The aim of this study was to assess the pharmacokinetics of two different formulations of argatroban in pigs after subcutaneous administration. Antithrombotic activity in plasma was determined by ecarin chromogenic assay. To visualize… CONTINUE READING